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4 edition of Characterization of the molecular nature of the interaction of human salivary histatins (histidine-rich proteins) with tannins found in the catalog.

Characterization of the molecular nature of the interaction of human salivary histatins (histidine-rich proteins) with tannins

Karol Wroblewski

Characterization of the molecular nature of the interaction of human salivary histatins (histidine-rich proteins) with tannins

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Published by National Library of Canada in Ottawa .
Written in English


Edition Notes

Thesis (M.Sc.) -- University of Toronto, 2000.

SeriesCanadian theses = -- Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches : negative. --
ID Numbers
Open LibraryOL22376869M
ISBN 100612497208
OCLC/WorldCa51736026

Proceedings - 34th European Peptide Symposium the Roche «Johannes Meinhofer Award » (), the Léon Velluz Award (). He is «. Chevalier dans l'Ordre des Palmes Académiques » (), and Chevalier .. the region of Ljulin mountain according to the procedure described by Lai et. al [1]. A solution of lyophilized skin secretion was passed through a Centricon. the practical / clinical work. The work is graded and the log book provides data on student‘s performance throughout the year. The log book evaluation forms part of the internal assessment as well as University examination. While day-to-day work is signed by the faculty / tutor, the log book is signed by the Department Head. The relationship of salivary molecule concentration to blood (or saliva/plasma ratio; S/P) is influenced by serum/saliva pH, molecular pKa, molecular weight, lipophilicity, and protein binding.   Raj et al., “Structure of Human Salivary Histatin 5 in Aqueous and Nonaqueous Solutions,” Biopolymers, vol. 45, , pp. Tailor et al., “A Novel Family of Small Cysteine-rich Antimicrobial Peptides from Seed of Impatiens balsamina is Derives from a Single Precursor Protein,” The Journal of Biological Chemistry, vol. , No.

In the past, the characterization of even a single human gene was a painstaking process, requiring years of effort. Recent developments in the areas of cloning vectors, DNA sequencing, and computer technology have merged to greatly accelerate the rate at which human genes can be isolated, sequenced, mapped, and characterized.


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Characterization of the molecular nature of the interaction of human salivary histatins (histidine-rich proteins) with tannins by Karol Wroblewski Download PDF EPUB FB2

Q FEBS The molecular nature of histatin– polyphenol interaction (Eur. Biochem. ) Penta-O-galloyl-β-D-glucose and (-).epigallocatechin gallate: cancer preventive agents, Chapter. Vanderspek JC, Offner GD, Troxler RF, Oppenheim FG () Molecular cloning of human submandibular histatins.

Arch Oral Biol – PubMed CrossRef Google Scholar Veerman ECI, Nazmi K, Van ‘t Hof W, Bolscher JGM, Den Hertog AL, Nieuw Amerongen AV () Reactive oxygen species play no role in the candidacidal activity of the salivary Cited by: 5. Polyphenols (tannins) in the diet not only precipitate oral proteins, producing an astringent sensation, but also interact with dietary proteins and digestive enzymes in the gut, resulting in a variety of antinutritive and toxic effects.

Salivary proline-rich proteins (PRPs), which are secreted into the oral cavity, form complexes with and precipitate dietary polyphenols, and thus, they. From the sequences obtained, it is likely that these peptides are derived from proteolysis of the hydroxyapatite-interactive human salivary proteins, histatins, proline-rich proteins, and statherins.

Tannins are well-known food polyphenols that interact with proteins, namely, salivary proteins. This interaction is an important factor in relation to their bioavailability and is considered the basis of several important properties of tannins, namely, the development of astringency.

It has been generally accepted that astringency is due to the tannin-induced complexation and/or precipitation Cited by: Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins.

J Dent Res ;– PubMed Google ScholarCited by: 2. Fig. 2 shows the difference in density of the proteic bands that represent human saliva (HS) before and after interaction with seed (HS + Sd) and skin (HS + Sk) polyphenols.

For almost all proteins, there is substantial reactivity towards polyphenol sources, denoted by the reduction in band density. This is more marked for seed tannins which are more reactive toward salivary by:   This confirmed the interaction between EGCG and human salivary α-amylase.

The assay was confirmed by using porcine α-amylase as a standard (unpublished). Rotor Cited by: 2. Other main limitations of salivary diagnostics are the contamination and variable nature of saliva. 17 The complexity of biological and physiological processes creates new challenges on data processing and analysis, ability to quantify proteins and to analyze protein complexes, etc.

18 Therefore, it is recommended to focus more on salivary. Human saliva is an ideal body fluid for developing non-invasive diagnostics. Saliva contains naturally-occurring nanoparticles with unique structural and biochemical characteristics. The salivary exosome, a nanoscale extracellular vesicle, has been identified as a highly informative nanovesicle with clinically-relevant information.

Salivary exosomes have brought forth a pathway and mechanism Cited by: 5. The dietary consumption of grape and its products is associated with a lower incidence of degenerative diseases such as cardiovascular disease and certain types of cancers.

Most recent Characterization of the molecular nature of the interaction of human salivary histatins book has focused on the bioactive phenolic compounds in grape. Anthocyanins, flavanols, flavonols and resveratrol are the most important grape polyphenols because they possess many biological activities Cited by: Oviduct-specific glycoprotein also known as oviductal glycoprotein (OGP) or estrogen-dependent oviduct protein (EGP) or mucin-9 (MUC9) is a protein that in humans is encoded by the OVGP1 gene.

Function. Oviduct-specific glycoprotein is a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem s: OVGP1, CHIT5, EGP, MUC9, OGP. A large number of salivary components, including secretory immunoglobulin A, lactoferrin, lactoperoxidase, lysozyme, statherin and histatins, directly and indirectly regulate the microbiome Cited by:   Histatins, a novel family of histidine-rich proteins in human parotid secretion: isolation, characterization, primary structure, and fungistatic effects of Candida albicans.

J Cited by: 8. With the common name “dental plaque,” oral microbial communities are some of the most complex microbial floras in the human body, consisting of more than different bacterial species (1,).Extensive clinical studies have indicated that the oral microbial flora is responsible for two major human diseases: dental caries (tooth decay) and periodontitis (gum disease) (28,Cited by: Aim: The aim of the present review article is to establish a systematic review to describe the role of various salivary components such as pH, buffering capacity, proteins, electrolyte, antioxidant, enzymes, and minerals in occurrence and initiation of dental caries in participants with and without dental caries.

Results: A total of articles were retrieved through electronic by: 1. Mucins in human saliva are currently classed into two main categories, the high molecular weight MUC5B mucins and the low molecular weight MUC7 mucins.

In our study, a sedimentation coefficient for mucin of ~4S was compared against a standard, Sigma bovine submaxilllary mucin (4S), which had a molecular weight of ~ kDa (unpublished reports). AbstractHistatins are histidine-rich peptides present in the saliva of humans and higher primates and have been implicated in the protection of the oral cavity.

Histatin 1 is one of the most abundant histatins and recent reports show that it has a stimulating effect on cellular adherence, thereby suggesting a role in maintaining the quality of the epithelial barrier and stimulating mesenchymal Author: Irene A. van Dijk, Enno C.I.

Veerman, Eric A.J. Reits, Jan G.M. Bolscher, Jan Stap. The book then delivers in-depth examples of applications in human health and prospects for the future, including cytogenetics and molecular genetics, xenografts, and treatment of HIV and cancers.

All this is complemented by a discussion of the ethical and safety considerations in the field. The underlying mechanisms of Candida and candidiasis and promising new directions in drug discovery and treatment. Reviews all aspects of this common fungal pathogen and its impact on human health, from the basic biology of Candida albicans to the clinical management of candidiasis.

Reviews the latest basic and clinical research, focusing on findings in genome variability, host-pathogen. AbstractThis work describes the current state of research on the potential relationship between protein content in human saliva and dental caries, which remains among the most common oral diseases and causes irreversible damage in the oral cavity.

An understanding the whole saliva proteome in the oral cavity could serve as a prerequisite to obtaining insight into the etiology of tooth decay at Author: Galina Laputková, Vladimíra Schwartzová, Juraj Bánovčin, Michal Alexovič, Ján Sabo.

This chapter provides an in-depth account of defensins, and ties together the roles of other antimicrobial peptides and proteins that together contribute to mucosal innate host defense.

While the focus is on defensins and antimicrobial peptides from humans, peptides from other species are also included where appropriate. The structural and functional relationships between these three classes Cited by: Salivary secretion is under autonomic nervous control and thus regulated by the parasympathetic and sympathetic nervous system.

Impulses that arise from activation of chemoreceptors in the taste buds are carried to the salivatory nuclei in the medulla oblongata through the trigeminal (V), facial (VII), glossopharyngeal (IX) and vagal (X) nerves (NN.), whereas impulses from activation of Cited by:   Human salivary IgA inhibits the adherence of oral streptococci and Candida albicans to buccal epithelial cells (, ).

Although SIgA may inhibit the attachment of oral streptococci to teeth (,), they may also promote the adsorption of some strains (, ). An explanation for these contradictory results will be given below. WRKY transcription factor family (1, words) exact match in snippet view article find links to article sequences in the 50 upstream regions of genes coding for sporamin and beta-amylase from sweet Gen.

Genet.– Rushton, P.J. et al. The antimicrobials are specific in nature whereas immunomodulators provide broad spectrum capability against bacterial, viral and fungal diseases and thereby provide non-specific emergency-therapeutic approaches in the event of emergence of a strange pathogen or.

The characteristics of water from various sources depend on rain, nature of substratum on which it is in contact and the effect of other substances added to it. The chemical analysis of water is necessary to ascertain the quality of water. For human consumption, potable water should be used.

The day experimental gingivitis model, an established noninvasive model of inflammation in response to increasing bacterial accumulation in humans, is designed to enable the study of both the induction and resolution of inflammation.

Here, we have analyzed gingival crevicular fluid, an oral fluid comprising a serum transudate and tissue exudates, by LC−MS/MS using Fourier transform ion Cited by: The nature of the interaction between these salivary proteins and polyphenols depends on several factors, among which protein characteristics and the type of polyphenol.

Salivary proteins such as acidic PRPs and statherins present lower selectivity towards polyphenol structures, comparatively to histatins and cystatins [ 46 ].Author: Elsa Lamy, Martine Morzel, Lénia Rodrigues, Cristina Pinheiro, Ana Rodrigues Costa, Célia Miguel Ant. At the molecular level, the binding and precipitation of salivary proteins with astringent compounds is thought to form the basis for astringency, although the exact molecular mechanism and how it relates to the sensory perception is still unclear and is thought to vary with the nature of the astringent (Gibbins & Carpenter, ; Lee, Ismail Cited by: 2.

Full text of "Oral diseases [electronic resource]: textbook and atlas" See other formats. / - - Identification of the human salivary cystatin complex by the coupling of high-performance liquid chromatography and ion-trap mass spectrometry Schinina', Maria Eugenia; Gambarini, Gianluca - 01a Articolo in rivista.

Mucosal surfaces account for the vast majority of HIV transmission. In adults, HIV transmission occurs mainly by vaginal and rectal routes but rarely via oral route. By contrast, pediatric HIV infections could be as the result of oral route by breastfeeding. As such mucosal surfaces play a crucial role in HIV acquisition, and spread of the virus depends on its ability to cross a mucosal by: 75 a high local but low systemic concentration Further research may lead to a better understanding both its toxicity to humans and interaction with microbial targets, which could lead to more pharmaceutical and commercial interests.

Histatin-5 Histatins (Hs) are found in the saliva of higher primates and named due to their histidine rich. Wound licking is an instinctive response in humans and many other animals to lick ancats, small rodents, horses, and primates all lick wounds. Saliva contains tissue factor which promotes the blood clotting enzyme lysozyme is found in many tissues and is known to attack the cell walls of many gram-positive bacteria, aiding in defense against infection.

Abstract Book - HUPO Vancouver. This banner text can have markup. web; books; video; audio; software; images; Toggle navigation. salivary extract ruminant dietary polyphenols flemingia chemical adsorption antioxidant bindon goats wines grapes phenolic molecular foods lamy beltran acids extraction ruminants aqueous saliva mcrae heredia dairy Post a Review You can.

USB2 US13/, USA USB2 US B2 US B2 US B2 US A US A US Cited by: 1. Book Review. Book Review. October Junk DNA: A Journey through the Dark Matter of the Genome Characterization of the central neural projections to brown, white, and beige adipose tissue.

UBAP2L is amplified in a large subset of human lung adenocarcinoma and is critical for epithelial lung cell identity and tumor metastasis. Book with Online Access BX Molecular Medicine Encyclop(a)edia I User Interfaces and Human Computer Interaction UYZG T00 Histatins: multifunctional salivary antimicrobial peptides.- Structure-function relationships of antimicrobial chemokines.- Mechanisms and Significance of Bacterial Resistance to Human Cationic.Tsai H, Bobek LA.

Human salivary histatins: promising anti-fungal therapeutic agents. Crit Rev Oral Biol Med. ;– Peluso G, De Santis M, Inzitari R, Fanali C, Cabras T, Messana I, Castagnola M, Ferraccioli GF.

Proteomic study of salivary peptides and pro-teins in patients with Sjogren’s syndrome before and after File Size: 10MB.Oudhoff MJ, Bolscher JG, Nazmi K, et al. Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay.

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